DC10 – Antonio Marotta

Mapping S. aureus Glycan signatures and their recognition by host glycan binding proteins

GLYD

Name of your main supervisor and affiliation:
Title: Doctor and CEO
Name: Ludovic
Surname: Landemarre
Short name of your main supervisor affiliation: GLYD

Name of your co-supervisor(s) and their affiliation
Title: Professor
Name: Jeroen
Surname: Codée
Short name of your co-supervisor affiliation: ULEI

 

Starting date of your project:
06.10.2025

Could you give a few information about yourself and your scientific background, including previous studies and obtained degrees?

I gained both my Bachelor’s and Master’s degrees in Chemical Sciences at the University of Naples Federico II. During my studies, I developed a strong attraction for the glycoconjugates, exploring their structural and functional complexity through NMR and protein–carbohydrate interaction studies, which truly inspired my scientific curiosity.

Could you provide details about your scientific research, and previous projects, listing your key expertise and skills? 

All my previous projects focused on investigating the structural and immunological properties of bacterial glycoconjugates, working with gut-associated bacteria such as Bacteroides vulgatus and Fusobacterium nucleatum. I conducted LPS isolation, worked with synthetic LPS fragments, and analyzed protein–carbohydrate interactions, developing advanced expertise in NMR spectroscopy (¹H, HSQC, TOCSY, COSY, NOESY, HMBC) and ligand-based techniques such as STD-NMR. In parallel, I gained hands-on experience in recombinant protein expression and purification in HEK 293T and E. coli. These experiences strengthened my problem-solving, adaptability, and collaborative skills, preparing me to thrive in multidisciplinary research environments.

What was the motivation for joining the Aureus project?

I was excited to join AUREUS because it offers the chance to grow scientifically while contributing to impactful, international research. The project aligns with my background and allows me to apply my skills, learn new techniques, and help explore WTAs as targets against antibiotic-resistant pathogens.

What is the motivation and aim of your PhD project? 

I am motivated to pursue this PhD to address the urgent challenge of antibiotic-resistant MRSA by investigating host-pathogen interactions. My aim is to decipher how S. aureus wall teichoic acids (WTAs) interact with glycan-binding proteins using lectin glycosylating, WTA glycoconjugates, and PRR screening, providing insights for developing effective immune-based therapies and vaccines.

Could you write a few sentences about yourself, your hobbies, interests? 

I’m an outgoing person who enjoys meeting people. I’m also curious about discovering more from every aspect of life. In my free time, I love hanging out with friends and watching Napoli’s football matches — I’m a real “tifoso”.