DC12 – Laura Antonia Kaschnitz
Generating and characterizing anti-WTA mAb from human memory B cells using synthetic S. aureus WTA structures
AMC
Name of your main supervisor and affiliation:
Title: Prof. Dr.
Name: Nina
Surname: van Sorge
Short name of your main supervisor affiliation: AMC
Name of your co-supervisor(s) and their affiliation
Title: Prof. Dr.
Name: Andreas
Surname: Peschel
Short name of your co-supervisor affiliation: UT
Name of your co-supervisor(s) and their affiliation
Title: Dr.
Name: Astrid
Surname: Hendriks
Short name of your co-supervisor affiliation: AMC
Name of your co-supervisor(s) and their affiliation
Title: Dr.
Name: Robin
Surname: Temming
Short name of your co-supervisor affiliation: AMC
Starting date of your project: 01.10.2025
Could you give a few information about yourself and your scientific background, including previous studies and obtained degrees?
While I was born and raised in Austria, I moved to Heidelberg for my bachelor’s degree in molecular biotechnology. For my master’s degree, I switched to biochemistry, which was mainly focused on lab rotations. During this time, I spent 5 months in Zurich and came to Munich afterwards, where I performed my master’s thesis in cooperation with Roche.
Could you provide details about your scientific research, and previous projects, listing your key expertise and skills?
During my studies, I focused on immunology, microbiology and protein engineering. In previous projects, I worked on discovering antibodies against various targets using phage and yeast display. Furthermore, I researched novel antibiotic conjugates, increasing their efficacy to use them against resistant bacterial strains. During these projects, I gained experience in microbiology and cloning techniques, as well as antibody expression, production and characterization. In addition, I got familiar with mammalian cell culture and flow cytometry. Outside of the lab, my strengths lie in self-organization, communication and teamwork.
What was the motivation for joining the Aureus project?
With MRSA being one of the most prominent antibiotic-resistant pathogens, it is very important to investigate new treatment strategies. This project will connect researchers between academia and industry across Europe, and therefore provide lots of opportunities for professional and personal growth.
What is the motivation and aim of your PhD project?
In my project, I will focus on generating and characterizing IgM and IgG antibodies against the S. aureus surface polymer WTA. While IgG antibodies are often hindered in targeting S. aureus due to its virulence factor SpA, IgM antibodies are not affected by it. Through antibody engineering, new antibodies able to bind WTA could be identified, leading to new therapeutic agents against S. aureus.
Could you write a few sentences about yourself, your hobbies, interests?
In my free time, I can be found reading, trying out new recipes and spending time with friends. Otherwise, I enjoy skiing in the winter and traveling to new places. I am very looking forward to exploring the Netherlands.

