DC5 – Ilaria Liguori

Glycan Microarray for the Immune Recognition Study of S. aureus Teichoic Acids

Imperial College London

Name of your main supervisor and affiliation:
Title: Assistant Prof.
Name: Yan
Surname: Liu
Short name of your main supervisor affiliation: Imperial College London (UK)

Name of your co-supervisor(s) and their affiliation
Title: Prof.
Name: Franck
Surname: Fieschi
Short name of your co-supervisor affiliation: University of Grenoble-Alpes (FR)

Name of your Assistant-supervisor(s) and their affiliation
Title: Dr.
Name: Antonio
Surname: Di Maio
Short name of your co-supervisor affiliation: Imperial College London (UK)

 

Starting date of your project:
22/09/2025

Could you give a few information about yourself and your scientific background, including previous studies and obtained degrees?

I am Ilaria, born and raised in Naples, an enthusiastic and curious chemist with a BSc (2022) and MSc (2025) in Chemical Sciences from the University of Naples Federico II. With a strong focus on organic synthesis, I am ready to take the next step in my academic journey with a PhD in glycosciences. Determined and open-minded, I am eager to take on challenges and contribute to innovative research.

Could you provide details about your scientific research, and previous projects, listing your key expertise and skills?

During my Bachelor thesis, I synthesized novel selenoglycoconjugates by combining selenosugars with polyphenols such as caffeic acid and resveratrol. These compounds were designed to enhance antioxidant and antiviral properties against oxidative stress in viral diseases. Instead, my Master thesis explored the use of hexachloroacetone as a trichloroacetylating agent to develop selective protection/deprotection strategies for sugars and aminosugars under solvent-free conditions. Through these projects, I have been able to form myself as an organic chemist and consolidate my skills in organic synthesis, purification methods, and structural analysis, with emphasis on advanced NMR.

What was the motivation for joining the AUREUS project?

I was motivated to join this project by my interest in exploring the interface of chemistry, biochemistry and immunology, with a particular focus on glycobiology. I am eager to apply my background and skills while working in a collaborative and multidisciplinary environment across Europe.

What is the motivation and aim of your PhD project?

This project focuses on developing a novel Staphylococcus aureus WTA array, displaying the largest library to date of synthetic and natural fragments. The aim is to establish an immune recognition profile by screening key lectin receptors (e.g. CLRs, proteins of the complement system, scavenger receptors) and antibodies, providing insights into immune responses, vaccines, diagnostics and therapies.

Could you write a few sentences about yourself, your hobbies, interests?

I have always considered myself a curious person, and this curiosity for understanding nature’s mechanisms led me to become a scientist. In my free time, I enjoy sports, reading, and playing the piano, activities that help me relax, stay balanced, and express my creativity.